We report the case of a 61-year-old man known for hypercholesterolaemia, a history of smoking and positive family history, who presented with progressive dyspnoea without oppressive chest pain. Stress echocardiography showing inferior basal akinesia extending to the ­septum during maximal effort prompted a coronary angiogram.

The coronary angiogram demonstrated two significant lesions in the right coronary artery. The first situated was on the proximal portion (visually estimated to be 70% occlusion) and the second on the distal portion (visually estimated to be 70–90%) (fig. 1a). We first treated the proximal stenosis. We performed an angioplasty (NC EMERGE 3 × 12 mm – Boston Scientific^©) at a maximal pressure of 12 atm. for 50 seconds and implanted a bioresorbable scaffold (BRS) (Magmaris 3.5 × 15 mm – Biotronik^®) with an inflation of 12 atm. for 30 seconds.

An optical coherence tomography (OCT) revealed a 330–720 µm incomplete stent apposition (ISA) of the BRS, which was treated with two further balloon inflations (NC EMERGE 3.5 × 15 mm – Boston scientific^®) at 14 atm. for 23 seconds (fig. 2a₁, b₁, c₁, d₁, e₁,). Despite these inflations, the BRS ISA, measured as a maximum of 570 µm, persisted (fig. 2d₁). Because of this unsatisfactory OCT result, the distal lesion was treated with a conventional metallic everolimus drug-eluting stent (2.75 × 18 mm Xience Alpine – Abbott^®). The final angiographic end-result was satisfactory. The patient was prescribed aspirin 100 mg/d and prasugrel 10 mg/d for 12 months.

Thirteen months later, facing a persistent dyspnea, a new coronary angiogram was performed. The examination confirmed an excellent result post-stenting of the BVS on the right proximal coronary artery despite the initial ISA (panel b, fig. 1). An OCT (Dragon Fly Optis – St. Jude^®) confirmed the absence of stenosis and showed a complete dissolution of the BVS initially implanted (panels a2, b2, c3, d2 and e2, fig. 2). The 1-year follow-up OCT also revealed presence of struts residues with peristrut low intensity areas (PSLIA) and evaginations (panels b2, c2, d2, fig. 2) corresponding with the vessel wall areas where the BVS was initially well-apposed. On the contrary, the areas where te BVS was initially mal-apposed showed an intact artery wall and complete BRS resorption (panel d2 and e2,. fig. 2).

ISA is defined as an absence of contact between at least one stent strut and the intimal surface of the artery not overlying a side branch, and can be acute (at the time of implantation) or late [1]. The diagnosis is made by means of intravascular imaging, such as OCT. ISA reduces strut coverage [2, 3], which enhances the risk of stent thrombosis, particularly late stent thrombosis, as already ­described, for drug-eluting stents [4].

During the drug-eluting stent era, four distinct mechanisms of ISA were reported: (a) incomplete apposition of the stent in the vicinity of a severely calcified lesion with localised expansion of the platform (lever principle); (b) gradual recoil of a weak stent platform due to coronary pulsatility (chronic recoil); (c) dissolution of a former jailed thrombus or soft plaque (jailed thrombus); (d) positive remodelling of the coronary artery due to a hypersensitivity reaction, with subsequent ISA.

In this case, and despite good lesion preparation and optimal sizing, the Magmaris BRS had a non-trivial ISA that directly followed the proximal RCA bend ­(superior knee). The reason for ISA in this case probably reflects the weak radial strength of the BRS platform in the middle of the RCA bend. On the basis of the study by Onuma and colleagues [5], it is considered that magnesium alloy has a 5- to 6-fold lower tensile strength than cobalt chromium. Postdilatation did not affect the ISA. An aggressive postdilatation with larger balloons would not have improved the radial strength of the BRS and would have entailed a significant risk of strut rupture. Owing to rapid BRS resorption kinetics (within the 1-year period of dual antiplatelet therapy), the operator estimated that the risk of stent thrombosis of the Magmaris was lower with the residual ISA than in the case of rupture (and ­collapse) of the scaffold. Aggressive postdilatation has been promoted by Cuculi and colleagues [6]. The Luzern team presented an increased rate of stent thrombosis due to Magmaris rupture and collapse at the 2017 SSC (Swiss Cardiology Society) meeting held in Baden. In the case of Magmaris implantation, our opinion is that aggressive postdilatation is not mandatory. This case set a good example, since the 13-month OCT follow-up demonstrated that the Magmaris BRS was completely resorbed, and this patient did not experience any clinical event under “strong” dual antiplatelet therapy.